Tablets "Nimesan": instructions for use, composition, analogues and reviews

The drug "Nimesan" is popular in the market of medicines. It refers to non-steroidal anti-inflammatory drugs. The main active substance is nimesulide. This is confirmed by the Nimesan tablets instructions for use. They have an analgesic effect, help with inflammation, and also at elevated body temperature.

Dosage form and composition

The preparation is produced in the form of triangular tabletslight yellow color. What do they consist of? The Nimesan tablets include 100 mg of nimesulide, excipients: corn starch, lactose monohydrate, talc, crospovidone, propyl parahydroxybenzoate, magnesium stearate.

How to apply and in what dosages?

Is taken orally after a meal, fiftyand one hundred mg twice a day. If there is chronic hepatic insufficiency, then in a daily dose of one hundred mg. It is better to use the minimum dose, and reduce the course of treatment. Children aged 12 years are prescribed a single dose at a rate of 1.5 mg / kg of body weight, in the maximum daily dose of the drug - five mg / kg per day.

pharmachologic effect

As the instruction on the application totablets "Nimesan", in their structure contains sulfanilamide group. It is suggested that nimesulide is a selective inhibitor of cyclooxygenase (COX-2). The drug has anti-inflammatory, analgesic, as well as antipyretic effect. The mechanism of action of the drug "Nimesan" is associated with the oppression of prostaglandins. The synthesis of these compounds inhibit prostaglandin in a very strong inflammation, but on the mucosa of the stomach and kidneys it does not manifest because inhibited predominantly the second type of cyclooxygenase.

In addition, it should be noted that the mechanismanti-inflammatory effect of this medication is due to the ability to inhibit the formation of free oxygen radicals. This does not affect phagocytosis and hemostasis in any way.
This is confirmed by the Nimesan tablets instructions for use. The price is of interest to many buyers. In drugstores the drug costs from 165 rubles.

Pharmacokinetics

When ingested, the drug is good and fastabsorbed from the digestive tract. The maximum concentration of the active substance in the blood is observed already two hours after the first intake of the drug. In 99% it binds to proteins, and after a single dose of 100 mg the substance is found in the tissues of the sexual organs of women. Metabolised by the liver. The half-life of the drug from the blood is three hours. Active active substance is excreted together with urine within 24 hours.

Indications for use

Tablets "Nimesan" (instruction for use confirms this) is assigned in the following cases:

• Rheumatic diseases of various kinds occurring outside the joints;
• osteoarthritis;
• acute inflammatory processes in the upper respiratory tract, accompanied by fever;
• severe pain during menstruation;
• inflammatory processes and pain that have arisen after surgical intervention.

Contraindications to the use of the drug

Contraindications for the use of this medication include:

• the formation of ulcers in the stomach and duodenum, in an aggravated form;
• any degree of functional impairment of the liver;
• acute bleeding from the digestive tract;
• impaired renal function;
• lactation period;
• pregnancy;
• hypersensitivity to the active active substance of the drug - nimesulide and other NSAIDs.

All this is confirmed to the tablets "Nimesan" instructions for use and reviews. Dosage and route of administration:

• The maximum allowable daily dose of the drugfor adults is 400 mg (that is, four 100 mg tablets), for children 5 mg per day for 1 kg of body weight. Adults are prescribed to drink tablets of 100-200 mg, washed down with a large amount of water, twice a day after meals. Children are prescribed 1.5 mg per 1 kg of weight, also with water, two or three times a day after meals.

Side effects when taking

As a rule, tablets "Nimesan" (instructions for use are available in each pack) are well tolerated by the body, but sometimes still cause some side effects. These include:

• pain in the stomach, nausea, heartburn, in rare cases, there is a violation of the stool;
• dizziness, headaches, drowsiness;
• erythema, skin rash, urticaria;
• very rarely - fluid retention in the body, oliguria, systemic or local edema.

Reviews about tablets Shreya "Nimesan" considerbelow. Patient interaction: should be particularly careful during the simultaneous use of the drug with phenytoin, digoxin, lithium preparations, other NSAIDs.

special instructions

The drug "Nimesan" must be taken withcaution to patients with kidney failure, heart problems, visual impairment. During external application it is necessary to supervise a specialist for elderly patients who have renal, hepatic or heart failure. For children, special dosage forms should be used.

Due to the fact that the use of the drug mayto cause drowsiness and dizziness, one should be especially cautious of patients engaged in hazardous activities, where greater concentration of attention and rapid psychomotor reactions are required. This is confirmed by the pain-relieving "Nimesan" reviews of doctors.

Use by pregnant women

The drug is strictly contraindicated for use during pregnancy and during breastfeeding.

Interaction

The simultaneous application of "Nimesan" withdrugs that reduce blood coagulability, enhances this effect. Nimesulide may reduce the action of furosemide. Reduces the therapeutic effect of antihypertensive medications. The possibility of side effects with the use of methotrexate is increasing. Lithium and nimesulide simultaneously increase the level of the first in blood plasma. Nimesulide enhances the action of cyclosporin on the kidneys. Glucocorticosteroids, serotonin reuptake inhibitors increase the risk of bleeding from the gastrointestinal tract. In general, any drug must be combined with another very carefully, it should only be done under the supervision of a doctor.

Analogues of the "Nimesan"

Analogues include the following medicinalpreparations: Nimesulid, Nimulid, Naize, Nemuxle, Nimika, Nimesil, Aponil, Nimesulid-Teva. Analogues can cost cheaper or more expensive, it all depends on the manufacturer.

Reviews about the drug

In general, consumers note that the drug"Nimesan" quickly relieves pain, acts for five hours, has a convenient form of release in the form of tablets and a pleasant price. But it also has a large number of contraindications and side reactions, which, fortunately, are rarely observed. The doctors' comments about him are only positive. The product effectively reduces body temperature, relieves even severe pain.