"Spironolactone": analogues, instructions, application, description of the preparation

"Spironolactone" is a potassium and magnesium-savingdiuretic. The drug is a powerful diuretic that avoids the washing out of the body of vital salts. It also lowers the acidity of urine. This should be paid attention, trying to replace the "Spironolactone" in treatment. Analogues of medicines do not always have such properties.

Composition and form of release

The given preparation is issued in tabletedform. The active ingredient is spironolactone. One pill contains 25 or 100 mg of this substance. It also includes auxiliary components: potato starch, monohydrate, lactose, povidone, calcium stearate. Round tablets are packed in a cardboard pack of 20 pieces.

pharmachologic effect

The drug "Spironolactone" is an antagonistaldosterone. It is a hormone of the adrenal cortex. Aldosterone, combining with the protein receptors of the cells of the distal nephron, helps to reduce the excretion of sodium and water from the body, but increases the elution of potassium. "Spironolactone" competes with this hormone and acts directly opposite. The drug promotes the excretion of water and sodium from the body, while retaining potassium ions. The electrolyte balance is not disturbed.

At the present time pharmacodynamics is well studiedmedicament. When entering the gastrointestinal tract, it is quickly absorbed, binding to plasma proteins. Bioavailability of tablets is approximately 99%. One-time administration with food accelerates the absorption of the active active substance of the drug.

Therapeutic effect, according to the instructions, comesin 5 days. To activate the action of the drug requires its gradual accumulation in the body to a certain concentration. Otherwise, in medical practice this is called a cumulative effect. The active substance quickly penetrates into breast milk, and is excreted from the body together with feces and urine. At what diseases do doctors prescribe "Spironolactone"?

Indications for use

In the instructions to "Spironolactone" it is reported that the drug is intended for the treatment of the following diseases and pathologies:

• Edema syndrome, arising on the background of heart failure.
• Hyperaldosteronism.
• Essential hypertension.
• Secondary hyperaldosteronism caused by cirrhosis of the liver.

Treatment of a disease should be started after consultation with a doctor.

Contraindications

In what cases is it not recommended to take the drug"Spironolactone"? Indications for use, presented above, are not an excuse for self-treatment. This drug has a number of contraindications and side effects.

In the instructions to the medicine it is said that hisUse for therapeutic purposes is not recommended for people with Addison's disease, hypercalcemia, diabetes mellitus. With special care, the drug should be used in women with menstrual irregularities, enlarged mammary glands.

Instructions for use

This medication is intended for oralapplication. Its dosage is determined by the doctor individually, based on the severity of the disturbance of the water-electrolyte balance and hormonal background of the patient.

With edema caused by neuroticsyndrome, therapy is started with 100-200 mg of the drug per day. Dosage should be divided into two or three doses. The duration of the course of treatment is approximately three weeks. In the case of hyperaldosteronism and a low potassium content in the blood, the drug "Spironolactone-Darnitsa" is prescribed at a dosage of 300 mg per day.

With edematic syndrome associated with cardiacinsufficiency of chronic nature, the course of treatment is 5 days. Tablets are administered in a dosage of 100-200 mg. In addition, patients are usually prescribed thiazide and loop diuretics. With a positive dynamics of recovery, the dosage is gradually reduced to 25 mg per day.

Side effects

What side effects does"Spironolactone"? Analogues of this drug are characterized by poor tolerance. "Spironolactone", unlike them, is characterized by rapid assimilation and a good therapeutic effect. Occasionally, side effects are diagnosed, which are described in more detail below.

1. Metabolism: a change in the acid-base balance, hyperuricemia.
2. CNS: increased drowsiness, headaches, retardation.
3. The circulatory system: megaloblastosis, thrombocytopenia.
4. GASTROINTESTINAL TRACT: soreness in the abdomen, ulcers, intestinal colic, diarrhea.
5. Endocrine system: erectile dysfunction, breast carcinoma, coarsening of the voice.
6. Allergic reactions: itching, urticaria, rash.

If you experience the symptoms described aboveit is necessary to see a doctor. As a rule, the specialist decides to replace "Spironolactone". Analogues of this drug also have side effects, but they are less expressed.

special instructions

During treatment with "Spironolactone":

• It is recommended to avoid eating foods rich in potassium.
• Under strict prohibition are all alcoholic beverages.
• It should refrain from the simultaneous use of medicines, in which potassium is present.

If non-steroidal anti-inflammatory drugs are additionally prescribed for treatment, it is necessary to monitor kidney function and electrolyte performance in the blood.

At the initial stage of therapy, it is recommendedto refrain from driving a car and working with serious mechanisms that require high speed of psychomotor reactions and increased attention. The duration of this restriction is set individually, based on the tolerability of the drug "Spironolactone".

Drug price and storage conditions

The cost of the drug varies fromits dosage. For one packing of tablets it is necessary to give from 30 to 50 rubles. The final cost also depends on the markup, which is set by many pharmacy chains.

According to the instructions, it is recommended to store the drug at a temperature not exceeding 20 degrees, in a place inaccessible to children's hands. Shelf life is 3 years.

Medication analogues

What drugs can I replace"Spironolactone"? Analogues of this drug in most cases have a similar composition and concentration of the main component. These include the following drugs: "Veroshpilakton", "Aldakton", "Veroshpiron." The latter is most often used instead of the drug considered in this article.

Among the famous genericsthe following medicines: "Dekriz", "Inspra", "Espiro", "Epletor". By the mechanism of action they are all similar to "Spironolactone". Indications for use and biological digestibility do not differ. These diuretics are very effective in order to normalize blood pressure, removing excess fluid from the body. However, generics practically do not protect against the washing out of potassium and magnesium salts, so many doctors prefer to use the original drug.

Let's sum up the results

Now you know what pathologies anddisorders are prescribed "Spironolactone". The price of the drug and its ubiquitous availability are the two main criteria by which many patients prefer this particular medicine. Numerous positive reviews also prove the high efficiency of "Spironolactone".