The drug "Depot-Provera"

Depo-Provera is an injectable progestin(gestagen) of prolonged action. High doses of the drug can have an antitumoral effect on hormone-sensitive malignant formations. This effect is presumably due to the effect on hormone receptors (steroid) and pituitary-gonadal axis. The medication also has a pyrogenic effect (the ability to raise the temperature), in significant doses has the activity of a corticosteroid. The drug has a progestin property, does not have estrogenic and androgenic activity.

Depo-probe slowly absorbed afterintramuscular injection. In this regard, the constant concentration of the drug is maintained for a long time. The maximum content in the blood (plasma) is noted on the fourth-twentieth day after the injection. Residual concentrations can be detected even after seven to nine months after application.

Depo-probe penetrates into breast milk and through the blood-brain barrier. Metabolized medicine in the liver. It is excreted in urine and bile in unchanged form and in the form of metabolites.

Indications for the appointment of a depot-probe in the form ofpalliative or complementary treatment are hormone-dependent forms of breast tumors (breast cancer) in menopause in women, metastases or recurrences of endometrial cancer or kidney failure.

Initial dosage for kidney or endometrial cancer- 500 mg or 1 g per week. With improvement (stabilization), conditions for several months or weeks are prescribed maintenance treatment at 500 mg per week.

Therapy of cancer in the mammary gland is carried out onfor twenty-eight days. Dosage at the same time - 500 mg per day. At the end of this period, maintenance therapy is recommended. Dosage with this - twice a week for 500 mg. The drug is used until the reaction to the treatment is noted. In some cases, the results after the treatment of cancer in the breast (breast) can be observed after eight or ten weeks from the start of the drug. In case of detection of rapid progression on the background of therapy of pathology, the drug is canceled.

Adverse Reactions: urticaria, anaphylactoid condition, rash, thrombophlebitis, thromboembolism, insomnia, nervousness, weakness, drowsiness, dizziness, depression, headaches, nausea. Also, patients can note changes in the nature of vaginal discharge, galactorrhea, sensitivity in the chest. Against the background of the drug, it is possible to form a symptom complex of Itenko-Cushing.

Contraindicated drug during pregnancy and hypersensitivity to components.

Depo-probe 150 is used as acontraceptive medication. In this case, one injection is used in three months. Depot-test specialists are described as one of the safest contraceptives. The drug is allowed to use and nursing mothers (after delivery from the sixth week). According to experts, the advantages of injecting contraceptives are many times greater than the likelihood of adverse reactions.

It is also important that the full restoration of the childbearing function in a woman occurs six to eighteen months after the withdrawal of the drug.

The drug is used not only as a contraceptive. It is effective in anemia, endometriosis, climacteric syndrome, uterine bleeding (dysfunctional).

Use of the drug "Depot-Provera" reduces the likelihood of developing fibro-cystic mastopathy, endometrial cancer, pathologies in pelvic organs of an infectious and inflammatory nature, uterine myomas.