"Flemoklav Solutab" 875/125: instructions for use

In the pharmaceutical market of Russia there are hundredsvarious antibiotics, both domestic and imported. They are all designed to fight bacterial infections. There are synthetic, semi-synthetic antibiotics and natural antibiotics. The latter cause the least amount of side effects. But their action is directed, as a rule, against a small group of microbes.

There are also unprotected antibiotics andprotected, which include additional substances that prevent bacteria from protecting themselves from the deadly effect of the main therapeutic substance. What is special about it? Protected antibiotics can cope not only with a wide variety of infections, but they have more side effects than their unprotected counterparts.

In this article we will talk about the new protectedsemisynthetic preparation "Flemoklav Solutab" 875/125. The instruction to him explains how to use it, but not all medical terms in it can be understood by a wide range of people. We offer a detailed review of this drug, as well as an analysis of reviews of patients and doctors directly working with this drug.

General information

The accompanying "Flemoklave Solutab"875/125 the instruction informs that it is made by the Dutch company known on the Russian pharmaceutical market and named "Astellas Pharma Europe BV".

The medicine is an antibiotic withthe widest possible spectrum of action. It is produced in cardboard packages. Each pack contains only 2 blisters. In each of them 7 packs are packed in hermetically sealed cells. They are quite large in size, oblong, convex, do not have separation risks (that is, their division into parts during use is not provided). They have a company logo and numbers "424". This knowledge will help you to distinguish a natural drug from a fake.

The color of the Dutch tablets should be either white,or yellow-cream with brown impregnations. Their taste is quite specific, as reported by all respondents in their responses. For complete clarity of the picture, we present several photos of "Flemoklav Solutab" 875/125. The instruction prescribes tablets or swallows, washed down with water, or dissolved in water (100-150 ml) and drunk as a resulting suspension, since the drug belongs to the category of dispersible drugs.

Let us explain what this medical term means. Dispersible tablets are such medications that you do not need to swallow with water. They can dissolve in the mouth, and they can be dissolved in water and make a drug similar to a suspension. This kind of tablets was invented for patients suffering from dysphagia (having problems with swallowing), as well as for everyone who is more comfortable with this form of taking medicines.

Therefore, the taste of this drug is largevalue. "Flemoklav Solutab" is produced in two types. To be more precise, it is with lemon and orange flavor. If the flavoring agent of the tablets does not suit you at all and causes vomiting in the form of a suspension, it is allowed to add honey or sugar to the solution. It is also allowed to take this medicine with any product that you like (for example, with whipped fruit in the blender.

You can buy the drug in any pharmacy. It is only released by prescription. When buying the drug should pay special attention to the numbers following the name of the drug and always indicated on the package. The fact is that the "Flemoklav Solutab" Dutch company produces in several forms.

So, there are tablets of this agent with dosages.Amoxicillin and helping him to destroy clavulanic acid bacteria in the following proportions: 500/125, 250/62.5 and 125/31,25. All of them have the same healing properties. But if the package is purchased with a lower concentration of the main therapeutic components, the doctor must adjust the dosage of the drug.

The drug with a concentration of basic substances 875/125 costs from 380 to 490 rubles, which depends on the margins of pharmacies caused by transport and other expenses.

Chemical composition

The instructions to “Flemoklav Solutab” 875/125 indicate that there are only two main substances acting against bacteria in the preparation:

1. Amoxicillin. It contains 875 mg in each pill.
2. Clavulanic acid: 125 mg pills.

The numbers on the packaging “875” and “125” indicate precisely the content of these substances in the preparation. Additionally, each tablet contains:

• vanillin (1 mg);
• magnesium stearate (5 mg);
• saccharin (9 mg);
• Crospovidone (100 mg)
• cellulose microporous 327 mg;
• apricot flavoring.

Instructions to the "Flemoklav Solutab" 875/125 description of each component does not provide. We will fill this gap so that patients have an idea of ​​what is going into their bodies with each tablet of the drug.

Amoxicillin

This is a penicillin antibiotic. It belongs to the third subgroup, called aminopenicillins, and is a complex compound that includes, in addition to synthetic penicillins, substances such as ticarcillin and carbenicillin. This explains the unusually wide range of microorganisms with which he is able to fight.

The principle of their operation is to destroy the walls of bacteria by blocking the synthesis of their main component - peptidoglycan.

According to the instructions to "Flemoklav Solyutab"875/125, in the composition of the tablets means amoxicillin occupies a leading position. It should be borne in mind that although this substance is highly active against pathogenic microorganisms and is completely harmless to most people, in some patients it can cause allergic-type reactions: rash, laryngeal edema, fever up to 38 ^aboutC, abdominal pain, indigestion,even dangerous not only for health, but also for life anaphylactic shock. In rare cases, patients experience vomiting, peeling of the skin, dizziness.

Also note that such a strongAn antibiotic, like amoxicillin, with long-term use is able to destroy not only pathogenic bacteria, but also useful, inhabiting mucous membranes. This disrupts the normal balanced composition of the microflora, ensuring that the tissues perform their functions. This can provoke the occurrence of dysbacteriosis, and in women, in addition, the appearance of diseases such as jeracidia and vaginal candidiasis.

Clavulanic acid

As the instruction of the Flemoklav Solutub informs us875/125, in the composition of the drug approximately 1/5 part is occupied by clavulanic acid. This substance is an inhibitor of beta-lactamase enzymes. They are produced by many bacteria in order to ensure their resistance to antibiotics. By suppressing the activity of these enzymes, clavulanic acid reduces the resistance of microbes and enhances the antimicrobial functions of antibiotics. In addition, this component is able to destroy certain types of bacteria: streptococci, chlamydia, staphylococcus, genococcus, legionella. Working in pairs, clavulanic acid and amoxicillin are active against bacteria such as:

• streptococci (viridians, pyogenes, anthracis, pneumoniae);
• Staphylococcus aureus, epidermidis;
• enterococci;
• corynebacteria;
• clostridia;
• peptokokki;
• peptostreptococci;
• shigella;
• bordetella;
• gardnerella
• Klebsiella;
• salmonella;
• Escherichia;
• proteus;
• Helicobacter pylori.

This information is presented in the instructions."Flemoklava Solyutab" 875/125. However, it does not indicate that acting together, amoxicillin and clavulanic acid used with it stimulate the intracellular bactericidal activity of leukocytes, stimulate their chemotaxis (movement to the source of damage) and leukocyte adhesion (cell adhesion). All this greatly enhances the effect of the drug. Especially these beneficial properties are manifested in the treatment of respiratory infections caused by pneumococcus bacteria.

Additional substances in the composition of the drug

Crospovidone. This substance is called povidone in Russia. It belongs to the group of enterosorbents. Its properties are complexing. That is, povidone actively binds toxins: both from outside, and formed during various reactions in the body itself. It does not enter the blood, it works only in the digestive tract. At the same time, the mucous membranes do not break, do not accumulate in the cells, are excreted with feces.

The composition of the tablets "Flemoklava Solyutab" povidoneintroduced to adsorb toxins secreted by pathogenic bacteria, as well as remove other harmful substances from the body during metabolic reactions, thereby improving the therapeutic effect of the main drug components.

However, in some cases, povidone reducesdrug absorption. To prevent this from occurring while taking the considered drug, its quantitative content is precisely verified in it. There is no contraindication to povidone, but in rare cases it can cause nausea and vomiting.

Microporous cellulose. According to the instructions to "Flemoklav Solyutab"875/125, this substance in tablets is almost three times more than crospovidone. Microporous cellulose is a polysaccharide, it is not absorbed, not digested, does not cause allergic reactions. Once in the digestive tract, it absorbs pathogens like a sponge, that is, it acts as a sorbent.

Magnesium stearate. Used as filler and former.

The remaining components of the drug give tablets their taste.

Application area

As described by the instructions, the medicine "Flemoklav Solyutab" 875/125 is effective for the following diseases:

• respiratory infections (pneumonia, bronchitis, lung abscess);
• diseases of ENT organs (otitis, pharyngitis, sinusitis, tonsillitis);
• skin infections (erysipelas, dermatosis, impetigo, wound infections, cellulitis, abscesses);
• osteomyelitis;
• infections of the urinary and genital systems (cystitis, pyelitis, cervicitis, pyelonephritis, salpingitis, prostatitis, urethritis);
• some sexually transmitted diseases (gonorrhea, soft chancre);
• complications in obstetrics and surgery (postpartum sepsis, infections after surgery, septic abortion).

Pharmacokinetics

In the description of the drug "Flemoklav Solutab" 875/125the instruction says that, once in the stomach, clavulanic acid and the main drug of this medicine quickly penetrate the blood. The maximum plasma concentration for amoxicillin is 1.5 hours (12 µg / ml). Its absorption is 90% (when taken orally). Approximately 20% of this substance binds to proteins present in blood plasma.

It is experimentally determined that the periodThe half-life of a substance such as amoxicillin is 1.1 hours. It is excreted by the kidneys in an almost unchanged form, and approximately 80% is removed from the body within 6 (maximum 6.5) hours after the tablet has been drunk.

For clavulanic acid, time to reachmaximum (3 μg / ml) plasma concentration - 1 hour. About 60% is absorbed in the stomach, and about 22% is bound to plasma proteins. In humans, this substance is metabolized by hydrolysis and decarboxylation reactions. That is, it is already displayed in a modified form. And in the first 6-6.5 hours, about 50% is removed from the body.

Dosage and rules of administration

Consider how to take "Flemoklav Solyutab" 875/125. The instructions for dosage and methods of administration are as follows:

1. For children from 12 years old to take the drug1 tablet is allowed in the morning and 1 tablet in the evening. At what time it is not so important to do it. The main thing is that between receptions take place at least 12 hours. In the reviews, most patients indicate that they took the medicine at 8 am and at 8 pm.
2. Children who are less than 12 years old, but they weigh40 kg and more, you can also take tablets with an Amoxicillin content of 875 mg (Flemoklav Solutab 875/125). The instruction prescribes giving such children 2 tablets per day: 250 mg for children under 2 years of age, 500 mg for all others. Babies should be given medicine in the form of a syrup or sweet suspension.

Adults should take the drug in the same way as children over 12 years old, that is, on a tablet in the morning and evening.

Taking the drug while eating does not affect the process.absorption of active ingredients. However, many patients note that the medicine is better perceived by the body if taken immediately before the start of the meal.

The duration of treatment is determined by the doctor, based on the severity of the disease. In most cases, the course does not exceed 14 days, but under special circumstances it may be longer.

For people suffering from renal failureof any degree, the dosage of the Flemoklav Soluteb 875/125 can be adjusted. Instructions for use states that if a patient has a speed of the so-called glomerular filtration exceeds 30 ml / min, only then he is prescribed doses and frequency of administration on a common basis. In other words, 1 tablet in the morning and evening.

If the filtering rate is less than 30ml / min, the excretion of clavulanic acid and amoxicillin by the kidneys is slower. Therefore, reduce the dose of the drug to the patient (prescribed "Flemoklav Solutab" with amoxicillin content of 500 mg or can be used with 250 mg). Moreover, if the filtration rate is less than 30, but exceeds 10 mg per minute, the drug is taken 2 times a day, and if less than 10 mg / min, 1 time per day.

If the patient has renal failure, the drug is prescribed only if it is possible to constantly monitor liver function.

Those patients who perform hemodialysis,"Flemoklav Solyutab" is not contraindicated. Such people are prescribed a drug containing amoxicillin not higher than 500 mg. Oral pills are taken either twice a day (before and after the procedure) or once a day. It depends on the condition of the patient.

Contraindications

Like other remedies, a number of contraindications has the drug "Flemoklav Solutab" 875/125. The instruction states that it cannot be taken in the following categories of patients:

• with hypersensitivity to any components included in the composition of the drug;
• allergic to any penicillin preparations;
• those with liver dysfunction after the use of the drug will turn yellow in the eyes and skin;
• suffering from infectious mononucleosis;
• patients diagnosed with lymphocytic leukemia;
• with core-like rash on the body;
• with phenylketonuria.

Recall that a similar drug with a concentrationEssential substances 875/125 should not be taken in children under 12 years old and suffering from renal failure. At the same time take into account the glomerular filtration rate, which should not be below 10 mg / min.

Some categories of patients can withcaution and only under the supervision of a doctor to take the medicine "Flemoklav Solyutab" 875/125. The instructions for use indicate the following categories of such patients:

• having a gastrointestinal tract disease;
• patients with colitis;
• chronic renal failure;
• with severe liver failure;
• during pregnancy;
• in the period of breastfeeding.

A nursing mother can use this medicine for herself. But if the baby has diarrhea or candidiasis of the mucous membranes, the drug is canceled.

Adverse Reactions

Above mentioned adverse reactions thatThere may appear on every component included in Flemoklav Solyub875 / 125. The instructions for use of the drug reported that in general, the substances included in this medicine can cause the following undesirable reactions:

On the part of the digestive system:

• nausea;
• dysbacteriosis, manifested by diarrhea;
• vomiting;
• hemorrhagic colitis;
• enterocolitis;
• hepatitis;
• gastritis;
• cholestatic jaundice.

On the part of the organs responsible for blood formation:

• thrombocytosis;
• leukopenia;
• hemolytic anemia;
• thrombocytopenia;
• granulocytosis;
• eosinophilia.

From the side of the central nervous system:

• headache;
• convulsions;
• dizziness;
• unexplained anxiety;
• difficulty falling asleep.

Other:

• hematuria;
• candidiasis;
• crystalluria;
• interstitial nephritis.

In some patients, causes significantconcerns such information presented in the instructions to the "Flemoklav Solutab" 875/125. In the reviews of doctors to the drug, comments are also made about a too large list of adverse reactions to this drug. We add that its use in many adults and children can cause a number of allergic manifestations:

• skin rash;
• Stevens-Johnson syndrome;
• exudative erythema;
• acute exantomous pustus;
• allergic vasculitis;
• edema;
• exfoliative dermatitis;
• anaphylactic shock.

Interaction with other drugs

Not with all drugs canbe used, according to the instructions, "Flemoklav Solyutab." In a review, patients note that doctors did not always warn them about it, as a result of which undesirable reactions of the body occurred:

• Sulfonamides, linkosamides, macrolides, tetracyclines produce an antagonistic effect.
• Glucosamine, antacids, laxatives reduce absorption, and ascorbic acid increases it.
• Diuretics increase the amount of amoxicillin in the lymph.
• The drug reduces the effectiveness of oral contraception.

Analogues

The drug "Flemoklav Solutab" 875/125 has many analogues that have a similar antibacterial effect. Among them are:

• "Panklav".
• "Ecoclav".
• "Augmentin".
• "Arlet".

They are available in various quantities.content of the main components. Therefore, the dosage and methods of administration may differ from those prescribed for Flemoklava Solyub. In order for the treatment of analogues to be effective, it is necessary that the possibility of their use be determined by the attending physician. He must prescribe the dosage.

"Flemoklav Solutab" 875/125: about the instructions, feedback from doctors and patients

In general, this drug deserves attention andtrust. Physicians and specialists of a narrow profile prescribe it quite often, since in most cases the effect of the therapy is predictably high. With the help of such a drug, it is possible to cure patients of many serious bacterial infections and thus avoid their complications. Also, doctors note that this medicine has proven itself in the prevention of the development of postoperative complications.

Patients have a slightly different opinion about the drug."Flemoklav Solyutab" 875/125. In the feedback on the instructions attached to the packaging of the product, people note that it is sometimes difficult to understand when and how to give the drug to children.

But the most negative reviews are written aboutmultiple adverse reactions that have to interrupt treatment. In positive reviews, patients who did not experience any complications while taking the drug, noted the high efficacy of Flemoklav Solutab and its relatively low cost, which makes this medicine accessible to people with different income levels.