Antihypertensive tablets "Equator"

Tablets "Equator" area combined antihypertensive agent, the use of which helps reduce blood pressure, general vascular resistance and preload. The basis of this drug is a decrease in the concentration of aldosterone and angiotensin II in plasma, as well as an increase in the indicator of the bradykinin vasodilator. In addition, this combined agent prevents the entry of calcium ions into the smooth muscle cells of the vessels and myocardium due to the inhibition of the so-called calcium channels. Decrease in postload on the heart and expansion of peripheral arterioles and arteries similarly provides the drug "Equator". Tablets, the price of which is on average 450 rubles, also have a pronounced antianginal effect.

With regard to the composition of this antihypertensivemeans, as active (active) components it contains lisinopril and amlodipine besylate dihydrate. In the role of additional substances are sodium starch glycolate, magnesium stearate, microcrystalline cellulose 101 and 12.

The main indication for the appointment of sucha combined preparation, like the "Equator" pill, is essential hypertension. As a contraindication to the application are edema Quincke, angioedema edema diopathic or hereditary type, cardiogenic shock, myocardial infarction, allergic reaction to amlodipine besilate or lisinopril dihydrate. In addition, do not use this antihypertensive agent for arterial hypotension, hemodynamically significant aortic stenosis or mitral valve, unstable angina, heart failure and hypertrophic cardiomyopathy. Tablets from the pressure "Equator" is not recommended for prescribing to children of child age, pregnant and breast-feeding mothers.

With great caution this remedy is usedwith azotemia, ischemic heart disease, bradycardia, coronary insufficiency, tachycardia, cerebrovascular diseases, mitral stenosis, primary hyperaldosteronism, hyperkalemia, aortic stenosis, kidney and liver disorders, diabetes mellitus and lupus erythematosus.

Separately it is necessary to tell and about possible collateralreactions associated with the use of this combination drug. For example, tablets "Equator" can provoke headaches, weakness, drowsiness, dizziness, nausea, diarrhea, dry cough and vomiting. In addition, agranulocytosis, orthostatic hypotension, sleep disturbances, angioedema of the face, hyperkalemia, mood changes, bronchospasm, visual impairment, dyspnoea, rhinitis, gynecomastia, allergic alveolitis, tinnitus and nocturia can be observed. Arthralgia, skin rashes, itching, Reynaud phenomenon, tremor, myalgia, fatigue, paresthesia, asthenia, dyspepsia and hyperesthesia can also be provoked by therapy, the main place in which take the tablets "Equator".