Prednisolone: instructions for use, pharmacological properties
The form of the preparation "Prednisolone": soft medicinal form - ointment.
Farms
Prednisolone is a dehydrogenated analoghydrocortisone. Antiallergic, anti-inflammatory, antipruritic and antiexudative action with topical ointment "prednisolone" instruction causes a decrease in the formation, release and activity of inflammation mediators (kinin, a histamine, lysosomal enzymes, prostaglandins). Also, the migration of cells to the epicenter of inflammation is suppressed, vasodilation and increased vascular permeability appearing in the inflammatory focus are reduced. Reduction of exudation occurs due to the vasoconstrictor action of the drug "Prednisolone". The instruction indicates that the drug causes an immunosuppressive effect, inhibiting the action of complex antigen-antibody formations that accumulate on the walls of the vessels and are the cause of allergic vasculitis. The drug inhibits the effect of macrophages, cytokines, target cells, which cause the development of a reaction of the type of allergic contagious dermatitis. In this case, sensitized T-lymphocytes and macrophages can not access target cells.
Pharmacokinetics
When applying ointment "Prednisolone" is absorbed andthe active substance is in the bloodstream. In plasma, a significant proportion of prednisolone is associated with albumin and transcortin. Biotransformation of prednisolone occurs by oxidation, mainly in the liver, where glucuronization or sulfatization of oxidized forms occurs. In the form of metabolites is excreted from the body with urine and feces, in part - in an unchanged state. Prednisolone passes through the placental barrier, in small concentrations it can be found in the breast milk of a woman.
Prednisolone: indications
The drug is used in cases of manifestation:
- allergic and contact dermatitis,
- eczema,
- Atopic dermatitis,
- seborrheic dermatitis,
- psoriasis.
Prednisolone: instructions
The ointment is applied to the lesions in an even layer 1-3times / day. Duration of treatment is determined by the nature of the disease and usually lasts 8-14 days. In the treatment of ointment for children, the term of treatment should be reduced to 3-7 days, as the children's organism is more sensitive to the drug "Prednisolone". The instruction recommends to refuse warming, fixing and occlusive bandages.
Application features
The duration of ointment treatment should not bemore than 14 days to prevent possible side effects from the use of the drug "Prednisolone". Instruction prescribes to conduct treatment only under medical supervision.
Side effects
Usually the drug is well tolerated. Rarely, especially with prolonged use, itching, burning sensations, erythema are possible. In some patients, side effects can manifest as folliculitis, hypertrichosis, perioral dermatitis, allergic reactions to drug components. The above symptoms do not require treatment and are quickly eliminated when the drug is discontinued. It should be remembered that when ointments are applied to damaged skin and with prolonged use (especially when large areas of the skin are affected), systemic side effects may appear.
Interaction with other drugs
Prednisolone has the property of enhancinganticoagulant effect of anticoagulants. Increased the possibility of bleeding with the simultaneous administration of salicylates. Increases the likelihood of metabolic disorders with the simultaneous administration of diuretics. Increased risk of intoxication when using cardiac glycosides. Decreased hypoglycemic antidiabetic effect and decreases the antibacterial activity of rifampicin. It is not recommended to be used concomitantly with antacids.
Contraindications
Treatment with ointment "Prednisolone" instruction prohibits when:
hypersensitivity;
- bacterial, viral, fungal skin lesions;
- tuberculosis, syphilis, skin tumors, pregnancy, common acne and rosacea.
Overdose
Cases of overdose are unknown.
Storage conditions
Store under list B, at a temperature of 5-15 ° C. Shelf life - 2 years. Do not use after the expiry date.
Leave conditions
It is released by prescription.
