Features of the drug "Sibutramine." Reviews

The drug "Sibutramine", whose price is from 584 r., refers to the means used to treat obesity. The drug has a central effect. The mechanism of drug activity is based on the ability to selectively inhibit the reuptake of noradrenaline, serotonin and (to a lesser extent) dopamine. "Sibutramine hydrochloride" helps to accelerate and prolong the feeling of saturation. This, in turn, provokes a decrease in the need for food.

After penetration, a high absorption is noted. The drug is metabolized almost completely in the liver cells. The maximum concentration of the drug is observed after an hour.

Indications

The medicine "Sibutramine" (reviews of doctorstestify to this) effectively as a supporting therapy in the complex treatment for alimentary obesity with a mass index of 30 kg / m 2 and more, from 27 kg / m 2 and more, accompanied by other risk factors associated with overweight. Risk factors, in particular, include insulin-dependent type of diabetes mellitus, hyperlipidemia.

Dosing regimen

It is recommended to start taking in a dose of 10 mg / day. In case of insufficient effectiveness of this amount of the drug "Sibutramine" (the doctors' testimonies testify to this) it is advisable to increase the dosage to fifteen milligrams per day. In the absence of a therapeutic result, when taking medication in this dose, the remedy is canceled. Duration of the drug - no more than a year, due to the lack of information about safety during long-term treatment.

Adverse Reactions

The drug "Sibutramine" (reviews of doctorswarn about this) can trigger dry mouth, changes in appetite, constipation, paresthesia, a sense of anxiety. During treatment, patients experience dizziness, palpitations, tachycardia, convulsive seizures.

In a number of cases, there is an increase in activityenzymes in the liver, exacerbation of hemorrhoids, vasodilation, severe hypertension, increased heart rate. The drug can provoke thrombocytopenia, acute interstitial nephritis. As a rule, the negative consequences of taking Sibutramine medication (expert reviews confirm this) are developing at the initial stages of therapy (in the first month of treatment). When continuing treatment, their frequency and intensity are usually reduced.

Contraindications

Not recommended for obesityorganic nature, bulimia nervosa or anorexia and other serious eating disorders, ischemic heart disease, mental pathologies, decompensated stage of chronic heart failure. Contraindications include lactation, heart defects (congenital type), arrhythmias, pregnancy, disorders of hepatic functions of severe course, prostatic hyperplasia of benign nature. The drug is not recommended for drug or alcohol dependence, uncontrolled arterial hypertension, hyperthyroidism.