/ / Miller-Fisher Syndrome: symptoms, treatment, life expectancy

Miller-Fisher Syndrome: symptoms, treatment, life expectancy

One of the varieties of rare syndromeGuillain-Barre, which is an offshoot from a clear picture of the processes occurring in the body of a person afflicted with the disease, is the Miller-Fisher syndrome. It is characterized by a triad of signs, which are the same in all patients.

Fisher Miller Syndrome


Guillain-Barre syndrome is a rare occurrence. In medical practice, its indicators are 1-2 people per one hundred thousand people. It appears more often in men and has two peaks of its activity:

  • young age - 20-24 years;
  • the elderly - 70-74 years.

He is well known to neurologists and has a number ofcharacteristic features, confirmed by the delivery of analyzes of cerebrospinal fluid. In addition to the classic course of this disease, Fischer Miller syndrome, described by this American neurologist as early as 1956, is found.

Miller Fisher Syndrome


The disease is extremely rare and refers toacute inflammatory autoimmune diseases, in which myelinated nerve membranes are affected. In the beginning and with further development, the Miller-Fisher syndrome always manifests itself identically and consists of the following series of characteristic symptoms:

  • areflexia - there is a sharp fading, and in the future, a complete absence of reflexes of the limbs;
  • ataxia - cerebellar disorders;
  • ophthalmoplegia - paralysis of the muscles of the eye, often external, and in complex cases and internal;
  • tarapez and paralysis of the respiratory muscles - develop in severe, neglected cases.

With the correct definition of symptoms and timely treatment, the disease is benign, does not cause complications and often ends with spontaneous recovery.

syndrome Miller Fisher Symptoms


If you consult a doctor in a timely manner for a fewweeks or months, you can cure the Miller-Fisher syndrome. Up to how many live with a similar disease, it is not exactly clear how the causes of its appearance are not clear. But for most people with this diagnosis, experts promise the most favorable forecasts. Complete recovery of all functions in the body with proper and appropriate treatment, takes a maximum of ten weeks. And only a small number of patients with neglected cases require a number of additional medical measures.

Some medical professionals say that oftenthe cause of this pathology is the usual vaccination. In a number of cases, it was detected after severe viral diseases, sometimes the symptoms manifested after long-term treatment of a number of complex infections. Familiar and family cases of the development of the disease, suggesting a genetic predisposition of the organism to this pathology.

syndrome Miller Fisher to how many live

Clinical indicators

Leading complaints, which the patient provides, are primarily expressed in the following aspects:

  • weakness, loss of strength, lack of energy, possible dizziness;
  • difficulty with chewing, and a little later with a speech;
  • difficulty in walking and self-care;
  • frequent numbness of hands and feet, wavy pain in the limbs.

It is descending paralysis - a violation inmovement of the eyes, and then of other limbs (the sensation of the presence of gloves on the hands) is manifested by Miller-Fisher syndrome. Symptoms are very similar to Hein-Barre syndrome, but this type of pathology has a paralysis of an ascending nature - from the lower body to the upper one.

In addition to the weakness of the oculomotor muscles, impaired coordination and complete loss of reflexes, the patient may also have a number of secondary symptoms that contribute to a more accurate diagnosis.

  • The temperature sensitivity of the skin is much lower.
  • The patient is practically not sensitive to pain.
  • Swallowing saliva becomes difficult.
  • Speech is intermittent, words are hard to pronounce.
  • The gag reflex is absent.
  • Complaints about problems with the bladder.

Part of the symptoms, such as muscle weakness anddifficulties in speech, can arise completely spontaneously. They clearly indicate a serious complication of the situation and require immediate consultation of a specialist.

syndrome Miller Fisher Treatment


To accurately identify the Miller-Fisher syndrome, it is required to conduct a number of necessary studies.

  1. Mandatory approach to the neurologist, who conducts an examination and identifies all possible violations of a neurological nature.
  2. Spinal puncture is indicated. In most cases, it reveals the high protein values ​​characteristic of this disease.
  3. PCR analysis - allows you to determine the possible pathogen. It can be the herpes virus, Epstein-Barra, cytomegalovirus and others.
  4. Often, the specialist additionally appoints a CT scan, which helps to identify possible associated neurological pathologies.
  5. A mandatory blood test ispresence of anti-ganglioside antibodies. This is an obvious indicator of the presence of the inflammatory process, a positive result of this analysis becomes an accurate confirmation of the diagnosis.

The Miller-Fisher syndrome requires complex and accurate diagnostics, electroneuromyrography, differential analysis, comparing the symptoms with a number of similar diseases.

Fisher Miller Syndrome


Treatment of this disease includesa set of measures aimed at suppressing the immune response and purifying the blood from antibodies. Correct supportive and symptomatic therapy allows the complete elimination of Miller-Fisher syndrome in a short time. Treatment under the guidance of an experienced specialist leads to the most positive results and complete recovery. In extremely rare cases (only three percent of the total), relapses are possible, suggesting an additional course of complex therapy.

  1. An assessment of the respiratory system is performed, in cases where it is difficult for a patient to move independently, a hospital with permanent medical supervision is appointed.
  2. During the first five days (no later than two weeks after the first detection of symptoms), plasmapheresis and immunoglobulin are prescribed.
  3. To prevent possible vein thrombosis, anticoagulants are used.
  4. It requires constant monitoring of blood pressure, as its sharp changes can lead to serious complications.
  5. Additionally, classes are held with a speech therapist.
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