Mildronate tablets
"Mildronate" tablets are used for variousheart diseases, among which a special place is occupied by myocardial infarction, angina pectoris, chronic circulatory failure. They are also effective as a complex therapy of cerebral strokes, cerebrovascular insufficiency. The drug in combination with specific agents for the treatment of alcoholism is used to eliminate the withdrawal syndrome. "Mildronate" tablets are an effective remedy for eliminating physical overstrain, restoring working capacity.
This medicine hascardioprotective, anti-anginal, antihypoxic, angioprotective effect. In conditions of increased loads, the drug restores the balance between the delivery and the need of myocardial cells in oxygen, prevents the accumulation of pathological metabolic products, thus protecting the organs from damage, increasing the tone of the organism. "Mildronate" tablets have vasoconstrictive properties. The result of this action is the reduction of the lesion in myocardial infarction. With chronic heart failure the drug strengthens its contractile function, increases resistance to physical stress.
The drug "Mildronate" contains meldonium (an active substance), which is an analog of a complex compound of gamma-butyrobetaine, which is contained in all cells of the human body.
The drug has a high level of bioavailability. It also has a high absorption coefficient in the gastrointestinal tract. The maximum concentration is observed two hours after use. The drug is excreted in the urine after active metabolism in the kidney after six hours. With an increase in the dose, this figure, respectively, increases.
Mildronate tablets, instructions for whichindicates all indications and dosage methods, have several contraindications: hypersensitivity to components, increased values of intracranial pressure. The last complication is observed with violations of the outflow of venous blood, brain tumors. The question of the safety of the use of the drug during pregnancy, lactation remains unexplained. Therefore, during therapy with this drug should stop breastfeeding.
In some cases with the reception of "Mildronata"there is the appearance of allergic reactions (itching, rashes, edema, redness), dyspepsia, tachycardia, changes in blood pressure, psychomotor agitation.
When using this drug, it is necessaryConsider drug interactions with substances from other pharmacological groups. It enhances the effects of coronadulatory agents. Also significantly reduces the pressure when used with antihypertensive drugs. Combination with anticoagulants, antianginal agents, antiarrhythmics, antiaggregants, diuretics bronchodilators is allowed. Care should be taken when used together with peripheral vasodilators, antihypertensive agents, alpha-adrenoblockers, nifedipine, nitroglycerin, because this may lead to hypotension and moderate tachycardia. When these effects occur, you should stop using it to treat the drug Mildronate (tablets). Instruction for the use of the drug does not indicate the consequences of overdoses, since such cases have not been documented. Information on the effectiveness of use in children also does not. Shelf life of the drug is four years, later the active substance loses its pharmacological properties and the possibility of developing dangerous side effects increases.
