Antibodies to TPO and their effect on the hormonal system
Antibodies to teroperoxidase have an effect onthe state of the hormonal system of a person and affect his state of health and normal working capacity. The standard set of blood tests for hormones in the testing of the thyroid gland includes the determination of the level of TTG, T3, T4, CT3, CT4 and AT to TPO. Previously, antibodies to TPO in the medical literature were called antimycrosomal bodies.
In normal thyroid function, antibodiesto TPO in the blood are absent or present in very small doses. Their number increases dramatically with autoimmune diseases. The highest rates are recorded with thyroiditis Hashimoto. This disease usually occurs in elderly women. The probability of Hashimoto's thyroiditis being a member of one family is great, since although the disease itself is not inherited, predisposition to it is transmitted at the genetic level. People with chromosomal mutations have a higher risk of acquiring a disease.
Antibodies to TPO are also found in individuals,suffering from Graves' disease. With diffuse hyperfunctioning goiter, the thyroid gland increases in size, the patient complains of tachycardia, arrhythmia, limb tremor, problems with eyelids and eyes. A slight excess of the admissible values of antibodies to TPO in the blood can speak of hypothyroidism. With hypothyroidism, metabolism slows down, the risk of obesity increases, and working capacity decreases, a person constantly feels fatigue, lethargy, there are problems with memorization and concentration of attention. If antibodies to TPO are found in the body of a pregnant woman, then the probability of developing thyrotoxicosis after the birth of a child is high. Developing in the womb of the mother baby, probably predisposed to hormonal disorders.
To test the thyroid gland,it is enough to pass the analysis. Antibodies to TPO are examined in serum, blood from the vein should be taken in the morning on an empty stomach. Before taking a biomaterial for study it is desirable to be at rest; The excited state can affect the secretion of hormones. One day before taking the test, you need to exclude heavy physical activity, alcohol and cigarettes.
What are the admissible values that canshow an analysis of antibodies to TPO? The antibody content rate ranges from 0 to 30 international units per milliliter. But if, according to the results of the research, the result is slightly higher than the norm, do not panic. With increased secretion of triiodothyronine and thyroxine antibodies to TPO are prevented from the development of hyperthyroidism and thyrotoxicosis. Nevertheless, the lower this indicator, the less likely to get an autoimmune disease in old age. After 30 years, the amount of antibodies to thyreperoxidase in serum becomes slightly higher.
Antibodies to TPO begin to be produced then,when the level of thyroid-stimulating hormone in the blood becomes higher. The more antibodies are present in the body, the more complex the secretion of T3 and T4, the slower the metabolism. Also, the cause of the appearance of antibodies can be an increase in the anti-inflammatory cytokine. In this case, an increase in the concentration of antibodies to thyroglobulin is observed.
Results of analysis for thyroid hormonesare prepared from one to three days. The cost of the analysis varies from 100 to 400 rubles, depending on the region. The indices of antibodies to TPO can not be estimated without data on the development of a thyroid-stimulating hormone, on the level of triiodothyronine and thyroxine, about the concentration in the blood of thyroid hormones in free, non-protein-related form. Only a comprehensive analysis of the results of hormonal studies will help the endocrinologist to choose the right treatment in each case.